Carotenoids from female Grapsus albolineatus as potential anti-ageing compounds

Styryl-Based and Tricyclic Compounds as Potential Anti-Prion Agents

Prion diseases currently have no effective therapy. These illnesses affect both animal and human populations, and are characterized by the conformational change of a normal self protein PrP(C) (C for cellular) to a pathological and infectious conformer, PrP(Sc) (Sc for scrapie). We used a well characterized tissue culture model of prion infection, where mouse neuroblastoma cells (N2a) were infe...

The Significance of Flavonoids as a Potential Anti-Tuberculosis Compounds

Mycobacterium tuberculosis, an agent of tuberculosis (TB), causes serious health problems such as multi drug resistance (MDR-TB), and extensive drug resistance (XDR-TB). According to WHO, 490,000 cases of MDR-TB and 40,000 cases of XDR-TB occur every year. There are several reasons to investigate a new class of antimicrobial drugs and the flavonoids represent a novel set of possibilities. Flavo...

Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs.

In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.5 µg/mL), followed by Aris...

Volatile Organic Compounds from Native Potato-associated Pseudomonas as Potential Anti-oomycete Agents

The plant kingdom represents a prominent biodiversity island for microbes that associate with the below- or aboveground organs of vegetal species. Both the root and the leaf represent interfaces where dynamic biological interactions influence plant life. Beside well-studied communication strategies based on soluble compounds and protein effectors, bacteria were recently shown to interact both w...

phenolic compounds as potential antioxidant